Launched in May 2017, this series is for health care providers treating service members and veterans with traumatic brain injury. Each episode offers a brief analysis of current research relevant to clinicians. Listen to or download episodes via SoundCloud, iTunes or Google Play.
In the first episode of CUBIST, we discuss research on how genetics and traumatic brain injury (TBI) interact to impact Alzheimer’s disease risk.
Released: May 2017
Hayes JP, Logue MW, Sadeh N, et al. Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease.Brain. 2017;140(3):813-825. doi: 10.1093/brain/aww344
PubMed link: https://www.ncbi.nlm.nih.gov/pubmed/28077398
In this episode, Dr. Don Marion discusses two new studies about neurocognitive assessment tools, or NCATs.
Released: June 2017
- Cole WR, Arrieux JP, Schwab K, Ivins BJ, Qashu FM, Lewis SC. Test-Retest Reliability of Four Computerized Neurocognitive Assessment Tools in an Active Duty Military Population. Arch Clin Neuropsychol. 2013 Nov;28(7):732-42. doi: 10.1093/arclin/act040.
Epub 2013 Jul 2.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/23819991
- Cole WR, Arrieux JP, Ivins BJ, Schwab KA, Qashu FM. A Comparison of Four Computerized Neurocognitive Assessment Tools to a Traditional Neuropsychological Test Battery in Service Members with and without Mild Traumatic Brain Injury. Arch Clin Neuropsychol. 2017 Apr 24:1-18. doi: 10.1093/arclin/acx036.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28444123
In this episode, Dr. Anne Bunner discusses a study about early predictors of long-term outcomes following blast-related concussion.
Released: June 2017
MacDonald C.L., Barber, J., Jordan, M., Johnson, A.M., Dikmen, S., Fann, J.R., & Temkin N. (2017). Early clinical predictors of 5-year outcome after concussive blast traumatic brain injury. JAMA Neurology. Advance online publication. doi: 10.1001/jamaneurol.2017.0143.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28459953
Link to interview with study’s lead author: www.kgw.com/news/health/study-h…-injuries/441539619
In this episode, Dr. Don Marion discusses a study on the usefulness of wearable sensors to measure head impacts.
Released: July 2017
Cortes, N., Lincoln, A., Myer, G.D., Hepburn, L., Higgins, M., Putukian, M., & Caswell S. (2017). Video analysis verification of head impact events measured by wearable sensors. American Journal of Sports Medicine. Published online. DOI: 10.1177/0363546517706703
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28541813
In this episode, Dr. Anne Bunner discusses recent updates to 2012 guidelines from the Concussion in Sport Group, also known as the “Berlin consensus statement” on sport concussion.
Released: July 2017
McCrory P, Meeuwisse W, Dvořák J, et al. Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med 2017;51:838-847.
PubMed link: https://www.ncbi.nlm.nih.gov/pubmed/28446457
In this episode, Dr. Anne Bunner and Dr. Don Marion discuss a study comparing rates of depression in men and women following a traumatic brain injury.
Released: August 2017
Lavoie, S., Sechrist, S., Quach, N., Ehsanian, R., Duong, T., Gotlib, I. H., & Isaac, L. (2017). Depression in Men and Women One Year Following Traumatic Brain Injury (TBI): A TBI Model Systems Study. Frontiers in Psychology, (8)634, eCollection. doi: 10.3389/fpsyg.2017.00634
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28529492
In this episode, Dr. Don Marion and Dr. Anne Bunner discuss objective and quantifiable imaging markers of traumatic brain injury in relation to aging.
Released: September 2017
Savjani RR, Taylor BA, Acion L, Wilde EA, & Jorge R. Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury. J Neurotrauma. 2017 Jun 28. doi: 10.1089/neu.2017.5022. [Epub ahead of print]
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28657432
In this episode, Dr. Don Marion and Dr. Anne Bunner discuss a study on the effects of roller coaster rides on the brain.
Released: September 2017
Kuo, C., Wu, L.C., Ye, P.P., Laksari, K., Camarillo, D.B., Kuhl E. (2017). Pilot Findings of Brain Displacements and Deformations during Roller Coaster Rides. Journal of Neurotrauma, epub ahead of print. doi: 10.1089/neu.2016.4893
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28683585
Dr. Don Marion and Dr. Anne Bunner discuss neuroimaging evidence of altered brain structure and function in concussed athletes with longer recovery times.
Released: October 2017
Churchill, N.W., Hutchison, M.G., Richards, D., Leung, G., Graham, S.J., & Schweizer, T.A. (2017). Neuroimaging of sport concussion: persistent alterations in brain structure and function at medical clearance. Scientific Reports 7, article number 8297. doi:10.1038/s41598-017-07742-3
Nature publications link: www.nature.com/articles/s41598-017-07742-3
Dr. Don Marion and Dr. Anne Bunner discuss the use of neurocognitive assessment tests following sport-related concussions.
Released: November 2017
Alsalaheen, B., Stockdale, K., Pechumer, D., Broglio, S.P., & Marchetti, G.F. (2017). A Comparative Meta-Analysis of the Effects of Concussion on a Computerized Neurocognitive Test and Self-Reported Symptoms. Journal of Athletic Training, 52(9): 834-846. doi.org/10.4085/1062-6050-52.7.05
Journal link: natajournals.org/doi/full/10.4085…062-6050-52.7.05
Dr. Don Marion and Dr. Anne Bunner discuss whether a drug known for treating Alzheimer’s, which may have some neuroprotective effects, could improve short-term neurological function in patients with moderate TBI.
Released: December 2017
Mokhtari, M., Nayeb-Aghaei, H., Kouchek, M., Miri, M.M., Goharani, R., Amoozandeh, A., Akhavan Salamat, S., Sistanizad, M. (2017). Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury. Journal of Clinical Pharmacology. Epub ahead of print. doi: 10.1002/jcph.980
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28724200
Dr. Don Marion and Dr. Anne Bunner discuss concussion assessment methods for high school athletes.
Released: December 2017
Currie, D.W., Kraeutler, M.J., Schrock, J.B., McCarty, E.C., Comstock, R.D. (2017). Time Trends in Concussion Symptom Presentation and Assessment Methods in High School Athletes. American Journal of Sports Medicine, 45(14), 3368-3373. doi: 10.1177/0363546517725068
PubMed link: www.ncbi.nlm.nih.gov/pubmed/28930492
In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss the new helmet safety rating system and how it impacted NFL player helmet use.
Released: December 2018
Colello, Raymond J., et al. “Making Football Safer: Assessing the Current National Football League Policy on the Type of Helmets Allowed on the Playing Field.” Journal of Neurotrauma, vol. 35, no. 11, Mar. 2018, pp. 1213–1223., doi:10.1089/neu.2017.5446.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/29421963
In this episode, Dr. Don Marion and Ms. Betsy Myhre discuss whether the presence of athletic trainers in high schools effects sports injury rates and patterns.
Released: March 2019
Pierpoint, L.A., LaBella, C.R., Collins. C.L., Fields, S.K., & Comstock, D. (2018). Injuries in Girls’ Soccer and Basketball: A Comparison of High Schools with and without Athletic Trainers. Epidemiology, 5:29.
In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss the efficacy of melatonin supplementation for sleep disturbances in patients with traumatic brain injury.
Released: April 2019
Grima, Natalie A., et al. “Efficacy of Melatonin for Sleep Disturbance Following Traumatic Brain Injury: a Randomised Controlled Trial.” BMC Medicine, vol. 16, no. 1, 19 May 2019, doi:10.1186/s12916-017-0995-1.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/29347988
In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss how a significant number of individuals post-mTBI may experience ongoing impairments and how standard post-mTBI symptom tools may not detect all impairments post injury.
Released: June 2019
Galea, Olivia A., et al. “Persistent Impairment Based Symptoms Post Mild Traumatic Brain Injury: Does a Standard Symptom Scale Detect Them?” Musculoskeletal Science and Practice, vol. 41, June 2019, pp. 15–22., doi:10.1016/j.msksp.2019.02.002.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/30825848
In this episode, Dr. Don Marion and Ms. Betsy Myhre discuss specific sport-related concussion cases.
Released: June 2019
Kontos, Anthony P., et al. “Sport-Related Concussion Clinical Profiles.” Current Sports Medicine Reports, vol. 18, no. 3, Mar. 2019, pp. 82–92., doi:10.1249/jsr.0000000000000573.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/30855306
In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss if statin therapy is associated with an increased or decreased risk of dementia after a concussion.
Released: July 2019
Redelmeier, Donald A., et al. “Association Between Statin Use and Risk of Dementia After a Concussion.” JAMA Neurology, 20 May 2019, doi:10.1001/jamaneurol.2019.1148.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/31107515
In this episode, Dr. Don Marion and Ms. Betsy Myhre discuss whether patients with mild traumatic brain injury (mTBI) are at risk for headaches following their injury.
Released: August 2019
Nordhaug, LH, et al. “Change in headache suffering and predictors of headache following mild traumatic brain injury. A population based, controlled, longitudinal study with 12 months follow-up.” Neurotrauma, 14 June 2019, doi: 10.1089/neu.2018.6328
PubMed link: www.ncbi.nlm.nih.gov/pubmed/31195890
On this episode of CUBIST, Betsy and Don discuss the article, "Acute elevation of serum inflammatory markers predicts symptom recovery after concussion."
Released: September 2019
Morgan E. Nitta, Jonathan Savitz, Lindsay D. Nelson, T. Kent Teague, James B. Hoelzle, Michael A. McCrea, Timothy B. Meier. "Acute elevation of serum inflammatory markers predicts symptom recovery after concussion." Neurology Jul 2019, 93 (5) e497-e507; DOI: 10.1212/WNL.0000000000007864
PubMed link: www.ncbi.nlm.nih.gov/pubmed/31270219
In season two, episode nine of CUBIST, Betsy and Don discuss the article, "Characterizing symptoms of traumatic brain injury in survivors of intimate partner violence.”
Released: October 2019
Smirl, J. D., Jones, K. E., Copeland, P., Khatra, O., Taylor, E. H., & Van Donkelaar, P. (2019). Characterizing symptoms of traumatic brain injury in survivors of intimate partner violence. Brain injury, 33(12), 1529-1538.
PubMed link: www.ncbi.nlm.nih.gov/pubmed/31442093