CUBIST — Clinical Updates in Brain Injury Science Today

Launched in May 2017, this series is for health care providers treating service members and veterans with traumatic brain injury. Each episode offers a brief analysis of current research relevant to clinicians. Listen to or download episodes via SoundCloud, iTunes or Google Play.

In the first episode of CUBIST, we discuss research on how genetics and traumatic brain injury (TBI) interact to impact Alzheimer’s disease risk.

Released: May 2017

Publication discussed:
Hayes JP, Logue MW, Sadeh N, et al. Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease.Brain. 2017;140(3):813-825. doi: 10.1093/brain/aww344

PubMed link: https://www.ncbi.nlm.nih.gov/pubmed/28077398

In this episode, Dr. Don Marion discusses two new studies about neurocognitive assessment tools, or NCATs. 

Released: June 2017

Publications discussed:

  • Cole WR, Arrieux JP, Schwab K, Ivins BJ, Qashu FM, Lewis SC. Test-Retest Reliability of Four Computerized Neurocognitive Assessment Tools in an Active Duty Military Population. Arch Clin Neuropsychol. 2013 Nov;28(7):732-42. doi: 10.1093/arclin/act040.
    Epub 2013 Jul 2.
    PubMed link: www.ncbi.nlm.nih.gov/pubmed/23819991
  • Cole WR, Arrieux JP, Ivins BJ, Schwab KA, Qashu FM. A Comparison of Four Computerized Neurocognitive Assessment Tools to a Traditional Neuropsychological Test Battery in Service Members with and without Mild Traumatic Brain Injury. Arch Clin Neuropsychol. 2017 Apr 24:1-18. doi: 10.1093/arclin/acx036.
    PubMed link: www.ncbi.nlm.nih.gov/pubmed/28444123

In this episode, Dr. Anne Bunner discusses a study about early predictors of long-term outcomes following blast-related concussion.

Released: June 2017

Publication discussed:
MacDonald C.L., Barber, J., Jordan, M., Johnson, A.M., Dikmen, S., Fann, J.R., & Temkin N. (2017). Early clinical predictors of 5-year outcome after concussive blast traumatic brain injury. JAMA Neurology. Advance online publication. doi: 10.1001/jamaneurol.2017.0143.

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28459953

Link to interview with study’s lead author: www.kgw.com/news/health/study-h…-injuries/441539619

In this episode, Dr. Don Marion discusses a study on the usefulness of wearable sensors to measure head impacts.

Released: July 2017

Publication discussed:
Cortes, N., Lincoln, A., Myer, G.D., Hepburn, L., Higgins, M., Putukian, M., & Caswell S. (2017). Video analysis verification of head impact events measured by wearable sensors. American Journal of Sports Medicine. Published online. DOI: 10.1177/0363546517706703

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28541813

In this episode, Dr. Anne Bunner discusses recent updates to 2012 guidelines from the Concussion in Sport Group, also known as the “Berlin consensus statement” on sport concussion.

Released: July 2017

Publication discussed: 
McCrory P, Meeuwisse W, Dvořák J, et al. Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med 2017;51:838-847.

PubMed link: https://www.ncbi.nlm.nih.gov/pubmed/28446457

In this episode, Dr. Anne Bunner and Dr. Don Marion discuss a study comparing rates of depression in men and women following a traumatic brain injury.

Released: August 2017

Publication discussed: 
Lavoie, S., Sechrist, S., Quach, N., Ehsanian, R., Duong, T., Gotlib, I. H., & Isaac, L. (2017). Depression in Men and Women One Year Following Traumatic Brain Injury (TBI): A TBI Model Systems Study. Frontiers in Psychology, (8)634, eCollection. doi: 10.3389/fpsyg.2017.00634

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28529492

In this episode, Dr. Don Marion and Dr. Anne Bunner discuss objective and quantifiable imaging markers of traumatic brain injury in relation to aging.

Released: September 2017

Publication discussed:
Savjani RR, Taylor BA, Acion L, Wilde EA, & Jorge R. Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury. J Neurotrauma. 2017 Jun 28. doi: 10.1089/neu.2017.5022. [Epub ahead of print]

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28657432

In this episode, Dr. Don Marion and Dr. Anne Bunner discuss a study on the effects of roller coaster rides on the brain.

Released: September 2017

Publication discussed:
Kuo, C., Wu, L.C., Ye, P.P., Laksari, K., Camarillo, D.B., Kuhl E. (2017). Pilot Findings of Brain Displacements and Deformations during Roller Coaster Rides. Journal of Neurotrauma, epub ahead of print. doi: 10.1089/neu.2016.4893

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28683585

Dr. Don Marion and Dr. Anne Bunner discuss neuroimaging evidence of altered brain structure and function in concussed athletes with longer recovery times.

Released: October 2017

Publication discussed:
Churchill, N.W., Hutchison, M.G., Richards, D., Leung, G., Graham, S.J., & Schweizer, T.A. (2017). Neuroimaging of sport concussion: persistent alterations in brain structure and function at medical clearance. Scientific Reports 7, article number 8297. doi:10.1038/s41598-017-07742-3

Nature publications link: www.nature.com/articles/s41598-017-07742-3

Dr. Don Marion and Dr. Anne Bunner discuss the use of neurocognitive assessment tests following sport-related concussions.

Released: November 2017

Publication discussed:
Alsalaheen, B., Stockdale, K., Pechumer, D., Broglio, S.P., & Marchetti, G.F. (2017). A Comparative Meta-Analysis of the Effects of Concussion on a Computerized Neurocognitive Test and Self-Reported Symptoms. Journal of Athletic Training, 52(9): 834-846. doi.org/10.4085/1062-6050-52.7.05

Journal link: natajournals.org/doi/full/10.4085…062-6050-52.7.05

Dr. Don Marion and Dr. Anne Bunner discuss whether a drug known for treating Alzheimer’s, which may have some neuroprotective effects, could improve short-term neurological function in patients with moderate TBI.

Released: December 2017

Publication discussed:
Mokhtari, M., Nayeb-Aghaei, H., Kouchek, M., Miri, M.M., Goharani, R., Amoozandeh, A., Akhavan Salamat, S., Sistanizad, M. (2017). Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury. Journal of Clinical Pharmacology. Epub ahead of print. doi: 10.1002/jcph.980

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28724200

Dr. Don Marion and Dr. Anne Bunner discuss concussion assessment methods for high school athletes.

Released: December 2017

Publication discussed:
Currie, D.W., Kraeutler, M.J., Schrock, J.B., McCarty, E.C., Comstock, R.D. (2017). Time Trends in Concussion Symptom Presentation and Assessment Methods in High School Athletes. American Journal of Sports Medicine, 45(14), 3368-3373. doi: 10.1177/0363546517725068

PubMed link: www.ncbi.nlm.nih.gov/pubmed/28930492

In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss the new helmet safety rating system and how it impacted NFL player helmet use.

Released: December 2018

Publication discussed:
Colello, Raymond J., et al. “Making Football Safer: Assessing the Current National Football League Policy on the Type of Helmets Allowed on the Playing Field.” Journal of Neurotrauma, vol. 35, no. 11, Mar. 2018, pp. 1213–1223., doi:10.1089/neu.2017.5446.

PubMed link: www.ncbi.nlm.nih.gov/pubmed/29421963

In this episode, Dr. Don Marion and Ms. Betsy Myhre discuss whether the presence of athletic trainers in high schools effects sports injury rates and patterns.

Released: March 2019

Publication discussed:
Pierpoint, L.A., LaBella, C.R., Collins. C.L., Fields, S.K., & Comstock, D. (2018). Injuries in Girls’ Soccer and Basketball: A Comparison of High Schools with and without Athletic Trainers. Epidemiology, 5:29. 

https://doi.org/10.1186/s40621-018-0159-6

In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss the efficacy of melatonin supplementation for sleep disturbances in patients with traumatic brain injury.

Released: April 2019

Publication discussed:
Grima, Natalie A., et al. “Efficacy of Melatonin for Sleep Disturbance Following Traumatic Brain Injury: a Randomised Controlled Trial.” BMC Medicine, vol. 16, no. 1, 19 May 2019, doi:10.1186/s12916-017-0995-1. 

PubMed link: www.ncbi.nlm.nih.gov/pubmed/29347988

In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss how a significant number of individuals post-mTBI may experience ongoing impairments and how standard post-mTBI symptom tools may not detect all impairments post injury.

Released: June 2019

Publication discussed:
Galea, Olivia A., et al. “Persistent Impairment Based Symptoms Post Mild Traumatic Brain Injury: Does a Standard Symptom Scale Detect Them?” Musculoskeletal Science and Practice, vol. 41, June 2019, pp. 15–22., doi:10.1016/j.msksp.2019.02.002.

PubMed link: www.ncbi.nlm.nih.gov/pubmed/30825848

In this episode, Dr. Don Marion and Ms. Betsy Myhre discuss specific sport-related concussion cases.

Released: June 2019

Publication discussed:
Kontos, Anthony P., et al. “Sport-Related Concussion Clinical Profiles.” Current Sports Medicine Reports, vol. 18, no. 3, Mar. 2019, pp. 82–92., doi:10.1249/jsr.0000000000000573.

PubMed link: www.ncbi.nlm.nih.gov/pubmed/30855306

In this episode, Ms. Betsy Myhre and Dr. Don Marion discuss if statin therapy is associated with an increased or decreased risk of dementia after a concussion.

Released: July 2019

Publication discussed:
Redelmeier, Donald A., et al. “Association Between Statin Use and Risk of Dementia After a Concussion.” JAMA Neurology, 20 May 2019, doi:10.1001/jamaneurol.2019.1148.

PubMed link: www.ncbi.nlm.nih.gov/pubmed/31107515

In this episode, Dr. Don Marion and Ms. Betsy Myhre discuss whether patients with mild traumatic brain injury (mTBI) are at risk for headaches following their injury.

Released: August 2019

Publication discussed:
Nordhaug, LH, et al. “Change in headache suffering and predictors of headache following mild traumatic brain injury. A population based, controlled, longitudinal study with 12 months follow-up.” Neurotrauma, 14 June 2019, doi: 10.1089/neu.2018.6328

PubMed link: www.ncbi.nlm.nih.gov/pubmed/31195890

On this episode of CUBIST, Betsy and Don discuss the article, "Acute elevation of serum inflammatory markers predicts symptom recovery after concussion."

Released: September 2019

Publication discussed:
Morgan E. Nitta, Jonathan Savitz, Lindsay D. Nelson, T. Kent Teague, James B. Hoelzle, Michael A. McCrea, Timothy B. Meier. "Acute elevation of serum inflammatory markers predicts symptom recovery after concussion." Neurology Jul 2019, 93 (5) e497-e507; DOI: 10.1212/WNL.0000000000007864

PubMed link: www.ncbi.nlm.nih.gov/pubmed/31270219

In season two, episode nine of CUBIST, Betsy and Don discuss the article, "Characterizing symptoms of traumatic brain injury in survivors of intimate partner violence.” 

Released: October 2019

Publication discussed:
Smirl, J. D., Jones, K. E., Copeland, P., Khatra, O., Taylor, E. H., & Van Donkelaar, P. (2019). Characterizing symptoms of traumatic brain injury in survivors of intimate partner violence. Brain injury, 33(12), 1529-1538.

PubMed link: www.ncbi.nlm.nih.gov/pubmed/31442093