State of the Science: Clinical, Metabolic and Pathologic Effects of Multiple Concussions

Jan. 16, 2014; 1-2:30 p.m. (ET)


During the past few years, professional athletes and their families have become increasingly concerned about the long-term neurologic effects of repeated concussions. The premature deaths of several professional football players have drawn attention to the relationship of multiple concussions with neurocognitive disorders that occurred decades after these injuries, although similar changes in the brain were associated with boxing and first described in the 1920s.

This webinar will examine the findings of laboratory and clinical studies on the mechanisms responsible for brain injury following one or multiple concussions. The presentation will address a particular focus on a class of proteins called Tau protein and the association of some of the histologic features of multiple concussions with those of Alzheimer's disease. At the conclusion of this webinar, participants will be able to:

  • Describe the pathophysiology of concussion
  • Summarize metabolic abnormalities caused by concussion, and the window of vulnerability of the brain to a second concussion
  • Identify the long-term changes in patterns of protein deposition possibly associated with multiple concussions
  • Articulate the possible association of multiple concussions and long-term cognitive deficits


Steven T. DeKosky, M.D., FAAN, FACP, FANA
Visiting Professor, Department of Medical Ethics and Health Policy Perelman School of Medicine at University of Pennsylvania Philadelphia, Pa. Professor of Neurology, Psychiatry and Behavioral Sciences, Director of the Alzheimer’s Disease Center University of Virginia School of Medicine Charlottesville, Va.
J. Clay Goodman, M.D., FAAN
Professor and Associate Dean Departments of Pathology and Immunology and Neurology Baylor College of Medicine Houston, Texas
David A. Hovda, Ph.D.
Director, University of California, Los Angeles (UCLA) Brain Injury Research Center Professor of Neurosurgery and Molecular and Medical Pharmacology David Geffen School of Medicine at UCLA Los Angeles, Calif.


Donald W. Marion, M.D., MSc.
Clinical Affairs Senior Adviser Defense and Veterans Brain Injury Center Silver Spring, Md.

Continuing Education

Continuing education is not available for this event.

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